Estrogenicity of novel phase I and phase II metabolites of zearalenone and cis-zearalenone.
Toxicon
; 105: 10-2, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26335359
ABSTRACT
Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, α-cis-zearalenol and ß-cis-zearalenol using the E-Screen assay. Overall, a change in the configuration from trans to cis retains significant estrogenic activity. In contrast, alterations of the aromatic moiety including hydroxylation and sulfation showed a markedly decreased estrogenicity when compared to zearalenone.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Zearalenona
/
Estrógenos
Límite:
Humans
Idioma:
En
Revista:
Toxicon
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania