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Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus.
Nurjadi, D; Schäfer, J; Friedrich-Jänicke, B; Mueller, A; Neumayr, A; Calvo-Cano, A; Goorhuis, A; Molhoek, N; Lagler, H; Kantele, A; Van Genderen, P J J; Gascon, J; Grobusch, M P; Caumes, E; Hatz, C; Fleck, R; Mockenhaupt, F P; Zanger, P.
Afiliación
  • Nurjadi D; Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany. Electronic address: dennis.nurjadi@uni-heidelberg.de.
  • Schäfer J; Tropenklinik, Paul-Lechler-Krankenhaus, Tübingen, Germany.
  • Friedrich-Jänicke B; Institute of Tropical Medicine and International Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Mueller A; Missionsärztliche Klinik, Würzburg, Germany.
  • Neumayr A; Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
  • Calvo-Cano A; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
  • Goorhuis A; Centre of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
  • Molhoek N; Instituut voor Tropische Ziekten, Havenziekenhuis, Rotterdam, The Netherlands.
  • Lagler H; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
  • Kantele A; Department of Medicine, University of Helsinki, Finland; Inflammation Centre, Clinic of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Unit of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Van Genderen PJ; Instituut voor Tropische Ziekten, Havenziekenhuis, Rotterdam, The Netherlands.
  • Gascon J; ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
  • Grobusch MP; Centre of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
  • Caumes E; Service de Maladies Infectieuses et Tropicales, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
  • Hatz C; Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zürich, Switzerland.
  • Fleck R; Tropenklinik, Paul-Lechler-Krankenhaus, Tübingen, Germany.
  • Mockenhaupt FP; Institute of Tropical Medicine and International Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Zanger P; Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany; Institute of Public Health, Unit of Epidemiology and Biostatistics, Heidelberg University Hospital, Heidelberg, Germany.
Clin Microbiol Infect ; 21(12): 1095.e5-9, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26344335
ABSTRACT
To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Staphylococcus aureus / Tetrahidrofolato Deshidrogenasa / Resistencia al Trimetoprim Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Staphylococcus aureus / Tetrahidrofolato Deshidrogenasa / Resistencia al Trimetoprim Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2015 Tipo del documento: Article