Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus.
J Virol
; 89(23): 12211-6, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26378170
ABSTRACT
Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Modelos Moleculares
/
Glicoproteínas Hemaglutininas del Virus de la Influenza
/
Sustitución de Aminoácidos
/
Gripe Humana
/
Subtipo H3N2 del Virus de la Influenza A
/
Pandemias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Virol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Bélgica