Telomerase activation by genomic rearrangements in high-risk neuroblastoma.

Peifer, Martin; Hertwig, Falk; Roels, Frederik; Dreidax, Daniel; Gartlgruber, Moritz; Menon, Roopika; Krämer, Andrea; Roncaioli, Justin L; Sand, Frederik; Heuckmann, Johannes M; Ikram, Fakhera; Schmidt, Rene; Ackermann, Sandra; Engesser, Anne; Kahlert, Yvonne; Vogel, Wenzel; Altmüller, Janine; Nürnberg, Peter; Thierry-Mieg, Jean; Thierry-Mieg, Danielle; Mariappan, Aruljothi; Heynck, Stefanie; Mariotti, Erika; Henrich, Kai-Oliver; Gloeckner, Christian; Bosco, Graziella; Leuschner, Ivo; Schweiger, Michal R; Savelyeva, Larissa; Watkins, Simon C; Shao, Chunxuan; Bell, Emma; Höfer, Thomas; Achter, Viktor; Lang, Ulrich; Theissen, Jessica; Volland, Ruth; Saadati, Maral; Eggert, Angelika; de Wilde, Bram; Berthold, Frank; Peng, Zhiyu; Zhao, Chen; Shi, Leming; Ortmann, Monika; Büttner, Reinhard; Perner, Sven; Hero, Barbara; Schramm, Alexander; Schulte, Johannes H

Peifer, Martin; Hertwig, Falk; Roels, Frederik; Dreidax, Daniel; Gartlgruber, Moritz; Menon, Roopika; Krämer, Andrea; Roncaioli, Justin L; Sand, Frederik; Heuckmann, Johannes M; Ikram, Fakhera; Schmidt, Rene; Ackermann, Sandra; Engesser, Anne; Kahlert, Yvonne; Vogel, Wenzel; Altmüller, Janine; Nürnberg, Peter; Thierry-Mieg, Jean; Thierry-Mieg, Danielle; Mariappan, Aruljothi; Heynck, Stefanie; Mariotti, Erika; Henrich, Kai-Oliver; Gloeckner, Christian; Bosco, Graziella; Leuschner, Ivo; Schweiger, Michal R; Savelyeva, Larissa; Watkins, Simon C; Shao, Chunxuan; Bell, Emma; Höfer, Thomas; Achter, Viktor; Lang, Ulrich; Theissen, Jessica; Volland, Ruth; Saadati, Maral; Eggert, Angelika; de Wilde, Bram; Berthold, Frank; Peng, Zhiyu; Zhao, Chen; Shi, Leming; Ortmann, Monika; Büttner, Reinhard; Perner, Sven; Hero, Barbara; Schramm, Alexander; Schulte, Johannes H.

Afiliación

Peifer M; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
Hertwig F; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Roels F; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Dreidax D; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Gartlgruber M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Menon R; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Krämer A; Division Neuroblastoma Genomics (B087), German Cancer Research Center, 69120 Heidelberg, Germany.
Roncaioli JL; Division Neuroblastoma Genomics (B087), German Cancer Research Center, 69120 Heidelberg, Germany.
Sand F; Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, 53127 Bonn, Germany.
Heuckmann JM; NEO New Oncology AG, 51105 Cologne, Germany.
Ikram F; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Schmidt R; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Ackermann S; Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center, Pittsburgh, Pennsylvania 15213, USA.
Engesser A; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Kahlert Y; NEO New Oncology AG, 51105 Cologne, Germany.
Vogel W; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Altmüller J; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Nürnberg P; Cologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Thierry-Mieg J; Institute of Biostatistics and Clinical Research, University of Münster, 48149 Münster, Germany.
Thierry-Mieg D; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Mariappan A; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Heynck S; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Mariotti E; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Henrich KO; Department of Prostate Cancer Research, Institute of Pathology, Center for Integrated Oncology Cologne-Bonn, University Hospital of Bonn, 53127 Bonn, Germany.
Gloeckner C; Cologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Bosco G; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Leuschner I; Cologne Center for Genomics, University of Cologne, 50931 Cologne, Germany.
Schweiger MR; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany.
Savelyeva L; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.
Watkins SC; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.
Shao C; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Bell E; NEO New Oncology AG, 51105 Cologne, Germany.
Höfer T; NEO New Oncology AG, 51105 Cologne, Germany.
Achter V; Division Neuroblastoma Genomics (B087), German Cancer Research Center, 69120 Heidelberg, Germany.
Lang U; NEO New Oncology AG, 51105 Cologne, Germany.
Theissen J; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
Volland R; Department of Pathology, University of Kiel, 24118 Kiel, Germany.
Saadati M; Functional Epigenomics, University of Cologne, 50931 Cologne, Germany.
Eggert A; Division Neuroblastoma Genomics (B087), German Cancer Research Center, 69120 Heidelberg, Germany.
de Wilde B; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Berthold F; Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Peng Z; Division Neuroblastoma Genomics (B087), German Cancer Research Center, 69120 Heidelberg, Germany.
Zhao C; Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Shi L; Computing Center, University of Cologne, 50931 Cologne, Germany.
Ortmann M; Computing Center, University of Cologne, 50931 Cologne, Germany.
Büttner R; Department of Informatics, University of Cologne, 50931 Cologne, Germany.
Perner S; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Hero B; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, University of Cologne, 50937 Cologne, Germany.
Schramm A; Division of Biostatistics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Schulte JH; Department of Pediatric Oncology and Hematology, Charité University Medical Center Berlin, 10117 Berlin, Germany.

Nature ; 526(7575): 700-4, 2015 Oct 29.

Article en En | MEDLINE | ID: mdl-26466568

Asunto(s)

Regulación Neoplásica de la Expresión Génica/genética; Genoma Humano/genética; Neuroblastoma/genética; Neuroblastoma/patología; Recombinación Genética/genética; Telomerasa/genética; Telomerasa/metabolismo; Línea Celular Tumoral; Transformación Celular Neoplásica/genética; Cromatina/genética; Cromatina/metabolismo; Cromosomas Humanos Par 5/genética; ADN Helicasas/genética; Metilación de ADN; Elementos de Facilitación Genéticos/genética; Activación Enzimática/genética; Amplificación de Genes/genética; Silenciador del Gen; Humanos; Lactante; Proteína Proto-Oncogénica N-Myc; Neuroblastoma/clasificación; Neuroblastoma/enzimología; Proteínas Nucleares/genética; Proteínas Oncogénicas/genética; Pronóstico; ARN Mensajero/análisis; ARN Mensajero/genética; Riesgo; Translocación Genética/genética; Regulación hacia Arriba/genética; Proteína Nuclear Ligada al Cromosoma X

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Recombinación Genética / Regulación Neoplásica de la Expresión Génica / Genoma Humano / Telomerasa / Neuroblastoma Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Infant Idioma: En Revista: Nature Año: 2015 Tipo del documento: Article País de afiliación: Alemania

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google