Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.
J Pharm Sci
; 105(2): 509-511, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26523769
ABSTRACT
To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the necessity to investigate the potential of the occurrence of additional nutrient-excipient interactions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Comprimidos Recubiertos
/
Cloruro de Calcio
Idioma:
En
Revista:
J Pharm Sci
Año:
2016
Tipo del documento:
Article
País de afiliación:
Alemania