Genetic susceptibility to autoimmune thyroid diseases in a Chinese Han population: Role of vitamin D receptor gene polymorphisms.
Ann Endocrinol (Paris)
; 76(6): 684-9, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26593863
ABSTRACT
PURPOSE:
Previous studies have found that some immune-related genes were associated with autoimmune thyroid diseases (AITDs). A couple of studies have explored the association between vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene polymorphisms and susceptibility to AITDs in different populations and found conflicting results. This case-control study was designed to evaluate the role of polymorphisms of VDR gene in the predisposition of AITDs in a Chinese Han population.METHODS:
A total of 417 patients with Graves' disease (GD), 250 patients with Hashimoto's thyroiditis (HT) and 301 healthy subjects were enrolled. The Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform was applied to detect four SNPs (rs1544410, rs2228570, rs731236 and rs7975232) in the VDR gene.RESULTS:
In the rs7975232 allele A frequency showed a significant increase in GD patients (30.34% vs. 25.42% in controls; P=0.041, OR=1.278, 95%CI=1.010-1.617). However, no relationship was found between clinical phenotypes and the four SNPs.CONCLUSIONS:
This result suggests that the VDR gene may be one susceptibility gene which contributes to the risk of GD.Palabras clave
Autoimmune thyroid disease (AITD); Graves' disease (GD); Hashimoto's thyroiditis (HT); Maladie de Basedow (GD); Maladies thyroïdiennes auto-immunes (MAIT); Polymorphisme de nucléotide unique (SNP); Récepteur à la vitamine D (VDR); Single nucleotide polymorphism (SNP); Thyroïdite de Hashimoto (HT); Vitamin D receptor (VDR)
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Graves
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Receptores de Calcitriol
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Enfermedad de Hashimoto
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Ann Endocrinol (Paris)
Año:
2015
Tipo del documento:
Article
País de afiliación:
China