Derivate isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis.

Chen, Lijuan; Tian, Hua; Li, Meng; Ge, Chao; Zhao, Fangyu; Zhang, Lixing; Li, Hong; Liu, Junxi; Wang, Tingpu; Yao, Ming; Li, Jinjun

Chen, Lijuan; Tian, Hua; Li, Meng; Ge, Chao; Zhao, Fangyu; Zhang, Lixing; Li, Hong; Liu, Junxi; Wang, Tingpu; Yao, Ming; Li, Jinjun.

Afiliación

Chen L; Shanghai Medical College, Fudan University, Shanghai, China.
Tian H; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiaotong University School of Medicine, Shanghai, China.
Li M; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiaotong University School of Medicine, Shanghai, China.
Ge C; Shanghai Medical College, Fudan University, Shanghai, China.
Zhao F; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiaotong University School of Medicine, Shanghai, China.
Zhang L; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiaotong University School of Medicine, Shanghai, China.
Li H; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiaotong University School of Medicine, Shanghai, China.
Liu J; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiaotong University School of Medicine, Shanghai, China.
Wang T; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiaotong University School of Medicine, Shanghai, China.
Yao M; Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory Fornatural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China.
Li J; College of Life Sciences and Chemistry, Tianshui Normal University, Tianshui, China.

Tumour Biol ; 37(5): 5951-61, 2016 May.

Article en En | MEDLINE | ID: mdl-26596832

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Aporfinas/farmacología; Animales; Apoptosis/efectos de los fármacos; Proteína beta Potenciadora de Unión a CCAAT; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patología; Proteínas de Ciclo Celular/metabolismo; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Modelos Animales de Enfermedad; Femenino; Puntos de Control de la Fase G2 del Ciclo Celular/efectos de los fármacos; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patología; Niacinamida/análogos & derivados; Niacinamida/farmacología; Proteínas Nucleares/metabolismo; Compuestos de Fenilurea/farmacología; Transducción de Señal/efectos de los fármacos; Sorafenib; Carga Tumoral; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Cell cycle; GADD45A; Hepatocellular carcinoma; d-ICD

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aporfinas / Antineoplásicos Fitogénicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: China

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