Antimycobacterial Natural Products from Endophytes of the Medicinal Plant Aralia nudicaulis.

Li, Haoxin; Doucet, Brandon; Flewelling, Andrew J; Jean, Stéphanie; Webster, Duncan; Robichaud, Gilles A; Johnson, John A; Gray, Christopher A

Li, Haoxin; Doucet, Brandon; Flewelling, Andrew J; Jean, Stéphanie; Webster, Duncan; Robichaud, Gilles A; Johnson, John A; Gray, Christopher A.

Nat Prod Commun ; 10(10): 1641-2, 2015 Oct.

Article en En | MEDLINE | ID: mdl-26669092

ABSTRACT

ABSTRACT

Antimycobacterial extracts of a Penicillium sp. (isolate HL4-159-41B) and a Coniothyrium sp. (isolate HL6-097-027B) isolated from the rhizomes of the Canadian medicinal plant Aralia nudicaulis were found to contain palitantin (1) and botrallin (2), craterellin C (3), mycosporulone (4), spiromassaritone (5), and massarigenin D (6) respectively. Bioassays against Mycobacterium tuberculosis H37Ra revealed that 1 - 4 possess moderate antimycobacterial activity.

Asunto(s)

Antituberculosos/farmacología; Aralia/microbiología; Ascomicetos/metabolismo; Endófitos/metabolismo; Mycobacterium tuberculosis/efectos de los fármacos; Antituberculosos/química; Ascomicetos/química; Endófitos/química; Células HEK293; Humanos; Estructura Molecular

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ascomicetos / Aralia / Endófitos / Mycobacterium tuberculosis / Antituberculosos Límite: Humans Idioma: En Revista: Nat Prod Commun Asunto de la revista: BOTANICA / FARMACOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article

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