Amyloid-ß Peptide Aß3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.

Gunn, Adam P; Wong, Bruce X; Johanssen, Timothy; Griffith, James C; Masters, Colin L; Bush, Ashley I; Barnham, Kevin J; Duce, James A; Cherny, Robert A

Gunn, Adam P; Wong, Bruce X; Johanssen, Timothy; Griffith, James C; Masters, Colin L; Bush, Ashley I; Barnham, Kevin J; Duce, James A; Cherny, Robert A.

Afiliación

Gunn AP; From the Florey Institute of Neuroscience and Mental Health.
Wong BX; From the Florey Institute of Neuroscience and Mental Health.
Johanssen T; Departments of Pathology and.
Griffith JC; Materials Characterisation and Fabrication Platform, University of Melbourne, Parkville, Melbourne 3010, Australia and.
Masters CL; From the Florey Institute of Neuroscience and Mental Health.
Bush AI; From the Florey Institute of Neuroscience and Mental Health, Departments of Pathology and.
Barnham KJ; From the Florey Institute of Neuroscience and Mental Health, Pharmacology and Therapeutics, and.
Duce JA; From the Florey Institute of Neuroscience and Mental Health, Departments of Pathology and the School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire LS2 9JT, United Kingdom.
Cherny RA; From the Florey Institute of Neuroscience and Mental Health, rcherny@unimelb.edu.au.

J Biol Chem ; 291(12): 6134-45, 2016 Mar 18.

Article en En | MEDLINE | ID: mdl-26697885

Asunto(s)

Péptidos beta-Amiloides/farmacología; Señalización del Calcio; Neuronas/metabolismo; Fragmentos de Péptidos/farmacología; Enfermedad de Alzheimer/metabolismo; Péptidos beta-Amiloides/química; Péptidos beta-Amiloides/metabolismo; Animales; Ácido Ascórbico/química; Permeabilidad de la Membrana Celular; Células Cultivadas; Cobre/química; Humanos; Peroxidación de Lípido; Ratones Endogámicos C57BL; Fragmentos de Péptidos/química; Fragmentos de Péptidos/metabolismo; Agregado de Proteínas; Ácido Pirrolidona Carboxílico/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Tirosina/análogos & derivados; Tirosina/metabolismo

Palabras clave

Alzheimer disease; amyloid-beta (Aß); dityrosine; lipid peroxidation; oligomer; pyroglutamate; reactive oxygen species (ROS)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Señalización del Calcio / Neuronas Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article

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