Your browser doesn't support javascript.
loading
Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis.
Donadieu, Maxime; Le Fur, Yann; Lecocq, Angèle; Maudsley, Andrew A; Gherib, Soraya; Soulier, Elisabeth; Confort-Gouny, Sylviane; Pariollaud, Fanelly; Ranjeva, Marie-Pierre; Pelletier, Jean; Guye, Maxime; Zaaraoui, Wafaa; Audoin, Bertrand; Ranjeva, Jean-Philippe.
Afiliación
  • Donadieu M; Aix Marseille Université, CNRS, CRMBM UMR 7339, Medical School of Marseille, Marseille, France.
  • Le Fur Y; AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, Marseille, France.
  • Lecocq A; Aix Marseille Université, CNRS, CRMBM UMR 7339, Medical School of Marseille, Marseille, France.
  • Maudsley AA; AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, Marseille, France.
  • Gherib S; Aix Marseille Université, CNRS, CRMBM UMR 7339, Medical School of Marseille, Marseille, France.
  • Soulier E; AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, Marseille, France.
  • Confort-Gouny S; Miller School of Medicine, University of Miami, Department of Radiology, Miami, Florida, USA.
  • Pariollaud F; Aix Marseille Université, CNRS, CRMBM UMR 7339, Medical School of Marseille, Marseille, France.
  • Ranjeva MP; AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, Marseille, France.
  • Pelletier J; AP-HM, CHU Timone, Pôle de Neurosciences Cliniques, Department of Neurology, Marseille, France.
  • Guye M; Aix Marseille Université, CNRS, CRMBM UMR 7339, Medical School of Marseille, Marseille, France.
  • Zaaraoui W; AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, Marseille, France.
  • Audoin B; Aix Marseille Université, CNRS, CRMBM UMR 7339, Medical School of Marseille, Marseille, France.
  • Ranjeva JP; AP-HM, CHU Timone, Pôle d'Imagerie, CEMEREM, Marseille, France.
J Magn Reson Imaging ; 44(2): 411-9, 2016 08.
Article en En | MEDLINE | ID: mdl-26756662
ABSTRACT

PURPOSE:

To detect local metabolic abnormalities over the complete human brain in multiple sclerosis (MS) patients, we used optimized fast volumic echo planar spectroscopic imaging (3D-EPSI). MATERIALS AND

METHODS:

Weighted mean combination of two 3D-EPSI covering the whole brain acquired at 3T in AC-PC and AC-PC+15° axial planes was performed to obtain high-quality metabolite maps for five metabolites N-acetyl aspartate (NAA), glutamate+glutamine (Glx), choline (Cho), myo-inositol (m-Ins), and creatine+phosphocreatine (tCr). After spatial normalization, maps from 19 patients suffering from relapsing-remitting MS were compared to 19 matched controls using statistical mapping analyses to determine the topography of metabolic abnormalities. Probabilistic white matter (WM) T2 lesion maps and gray matter (GM) atrophy maps were also generated.

RESULTS:

Two-group analysis of variance (ANOVA) (SPM8, P < 0.005, false discovery rate [FDR]-corrected P < 0.05 at the cluster level with age and sex as confounding covariates) comparing patients and controls matched for age and sex showed clusters of abnormal metabolite levels with 1) decreased NAA (around -15%) and Glx (around 20%) predominantly in GM within prefrontal cortices, motor cortices, bilateral thalami, and mesial temporal cortices in line with neuronal/neuro-astrocytic dysfunction; 2) increased m-Ins (around + 20%) inside WM T2 lesions and in the normal-appearing WM of temporal-occipital lobes, suggesting glial activation.

CONCLUSION:

We demonstrate the ability to noninvasively map over the complete brain-from vertex to cerebellum-with a validated sequence, the metabolic abnormalities associated with MS, for characterizing the topography of pathological processes affecting widespread areas of WM and GM and its functional impact. J. Magn. Reson. Imaging 2016;44411-419.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética / Espectroscopía de Resonancia Magnética / Imagenología Tridimensional / Esclerosis Múltiple Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2016 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética / Espectroscopía de Resonancia Magnética / Imagenología Tridimensional / Esclerosis Múltiple Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2016 Tipo del documento: Article País de afiliación: Francia