Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.

Wu, Qian; Paul, Atanu; Su, Dan; Mehmood, Shahid; Foo, Tzeh Keong; Ochi, Takashi; Bunting, Emma L; Xia, Bing; Robinson, Carol V; Wang, Bin; Blundell, Tom L

Wu, Qian; Paul, Atanu; Su, Dan; Mehmood, Shahid; Foo, Tzeh Keong; Ochi, Takashi; Bunting, Emma L; Xia, Bing; Robinson, Carol V; Wang, Bin; Blundell, Tom L.

Afiliación

Wu Q; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
Paul A; Department of Genetics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Genes and Development Program, The University of Texas Graduate School of Biomedical Sciences at Houston, 6767 Bertner Avenue, Houston, TX 77030, USA.
Su D; Department of Genetics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Mehmood S; Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, OX1 3QZ Oxford, UK.
Foo TK; Department of Radiation Oncology, Robert Wood Johnson Medical School, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
Ochi T; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
Bunting EL; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK.
Xia B; Department of Radiation Oncology, Robert Wood Johnson Medical School, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
Robinson CV; Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, OX1 3QZ Oxford, UK.
Wang B; Department of Genetics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Genes and Development Program, The University of Texas Graduate School of Biomedical Sciences at Houston, 6767 Bertner Avenue, Houston, TX 77030, USA. Electronic address: bwang
Blundell TL; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK. Electronic address: tom@cryst.bioc.cam.ac.uk.

Mol Cell ; 61(3): 434-448, 2016 Feb 04.

Article en En | MEDLINE | ID: mdl-26778126

Asunto(s)

Proteína BRCA1/metabolismo; Neoplasias Óseas/metabolismo; Proteínas Portadoras/metabolismo; Núcleo Celular/metabolismo; Daño del ADN; Osteosarcoma/metabolismo; Secuencia de Aminoácidos; Proteínas de la Ataxia Telangiectasia Mutada/genética; Proteínas de la Ataxia Telangiectasia Mutada/metabolismo; Proteína BRCA1/química; Proteína BRCA1/genética; Neoplasias Óseas/genética; Neoplasias Óseas/patología; Proteínas Portadoras/química; Proteínas Portadoras/genética; Línea Celular Tumoral; Núcleo Celular/patología; Núcleo Celular/efectos de la radiación; Cristalografía por Rayos X; Mutación de Línea Germinal; Humanos; Modelos Moleculares; Datos de Secuencia Molecular; Osteosarcoma/genética; Osteosarcoma/patología; Fosforilación; Unión Proteica; Dominios y Motivos de Interacción de Proteínas; Multimerización de Proteína; Interferencia de ARN; Serina; Transfección

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Óseas / Daño del ADN / Proteínas Portadoras / Osteosarcoma / Núcleo Celular / Proteína BRCA1 Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido

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