Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity.

Martins, Karen A O; Cooper, Christopher L; Stronsky, Sabrina M; Norris, Sarah L W; Kwilas, Steven A; Steffens, Jesse T; Benko, Jacqueline G; van Tongeren, Sean A; Bavari, Sina

Martins, Karen A O; Cooper, Christopher L; Stronsky, Sabrina M; Norris, Sarah L W; Kwilas, Steven A; Steffens, Jesse T; Benko, Jacqueline G; van Tongeren, Sean A; Bavari, Sina.

Afiliación

Martins KAO; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA.
Cooper CL; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA.
Stronsky SM; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA.
Norris SLW; Research Support Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA.
Kwilas SA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA.
Steffens JT; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA.
Benko JG; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA.
van Tongeren SA; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA.
Bavari S; Molecular and Translational Sciences, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD, USA. Electronic address: sina.bavari.civ@mail.mil.

EBioMedicine ; 3: 67-78, 2016 Jan.

Article en En | MEDLINE | ID: mdl-26870818

Asunto(s)

Adyuvantes Inmunológicos; Linfocitos T CD4-Positivos/inmunología; Inmunidad; Vacunas/inmunología; Traslado Adoptivo; Animales; Anticuerpos Neutralizantes/inmunología; Anticuerpos Antivirales/inmunología; Linfocitos T CD4-Positivos/metabolismo; Citocinas/metabolismo; Modelos Animales de Enfermedad; Ebolavirus/inmunología; Femenino; Fiebre Hemorrágica Ebola/mortalidad; Fiebre Hemorrágica Ebola/prevención & control; Inmunización; Inmunoglobulina G/inmunología; Recuento de Linfocitos; Modelos Animales; Subgrupos de Linfocitos T/inmunología; Subgrupos de Linfocitos T/metabolismo; Vacunas/administración & dosificación; Vacunas de Partículas Similares a Virus/inmunología

Palabras clave

Adjuvant; BME, beta mercaptoethanol; CD, cluster of differentiation; DSCF, Dwass, Steel, Critchlow-Fligner; Durable protection; ELISA, Enzyme linked immunosorbent assay; ELISPOT, enzyme-linked immunospot assay; Ebola virus; FACS, fluorescence activated cell sorting; FBS, fetal bovine serum; GP, glycoprotein; IACUC, Institutional Animal Care and Use Committee; IM, intramuscular; IP, intraperitoneal; IQR, interquartile range; Immune correlates; LN, lymph node; MPLA, monophosphoryl lipid A; NAb, neutralizing antibody; Ns, not significant; PBS, phosphate buffered saline; PRR, pattern recognition receptor; Pfu, plaque forming unit; PsVNA, pseudovirion neutralization assay; TLR, Toll-like receptor; USAMRIID, United States Army Medical Research Institute of Infectious Diseases; VLP, virus-like particle; Vaccine; ma-EBOV, mouse-adapted Ebola virus

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas / Linfocitos T CD4-Positivos / Adyuvantes Inmunológicos / Inmunidad Límite: Animals Idioma: En Revista: EBioMedicine Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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