Frontal Lobe Degeneration in Adults with Down Syndrome and Alzheimer's Disease: A Review.
Dement Geriatr Cogn Disord
; 41(3-4): 123-36, 2016.
Article
en En
| MEDLINE
| ID: mdl-26891227
ABSTRACT
BACKGROUND:
There is a proven link between Down syndrome and the early development of the neuropathological features of Alzheimer's disease (AD). Changes in the personality and behavior of adults with Down syndrome might indicate the early stages of dementia or of frontotemporal lobar degeneration. The objective of this study was to investigate the executive functions and changes in behavior associated with frontal lobe degeneration in individuals with Down syndrome who develop AD. We conducted a systematic review selecting studies employing cognitive assessments.SUMMARY:
We identified few studies using objective measurements to determine whether cognitive aspects associated with the frontal lobe correlate with dementia in this population. We observed a tendency toward such correlations. KEY MESSAGES There is a need for further studies in which objective measures of cognitive and behavioral factors are evaluated together with data related to brain function and morphology.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Down
/
Enfermedad de Alzheimer
/
Lóbulo Frontal
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dement Geriatr Cogn Disord
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
/
PSIQUIATRIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Brasil