Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma.
Curr Neuropharmacol
; 15(1): 104-115, 2017.
Article
en En
| MEDLINE
| ID: mdl-26903150
ABSTRACT
Diffuse intrinsic pontine gliomas (DIPGs) are invariably fatal tumors found in the pons of elementary school aged children. These tumors are grade II-IV gliomas, with a median survival of less than 1 year from diagnosis when treated with standard of care (SOC) therapy. Nanotechnology may offer therapeutic options for the treatment of DIPGs. Multiple nanoparticle formulations are currently being investigated for the treatment of DIPGs. Nanoparticles based upon stable elements, polymer nanoparticles, and organic nanoparticles are under development for the treatment of brain tumors, including DIPGs. Targeting of nanoparticles is now possible as delivery techniques that address the difficulty in crossing the blood brain barrier (BBB) are developed. Theranostic nanoparticles, a combination of therapeutics and diagnostic nanoparticles, improve imaging of the cancerous tissue while delivering therapy to the local region. However, additional time and attention should be directed to developing a nanoparticle delivery system for treatment of the uniformly fatal pediatric disease of DIPG.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Puente
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Neoplasias del Tronco Encefálico
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Nanotecnología
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Glioma
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Antineoplásicos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Curr Neuropharmacol
Año:
2017
Tipo del documento:
Article