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Inhibition of ceramide de novo synthesis by myriocin produces the double effect of reducing pathological inflammation and exerting antifungal activity against A. fumigatus airways infection.
Caretti, Anna; Torelli, Riccardo; Perdoni, Federica; Falleni, Monica; Tosi, Delfina; Zulueta, Aida; Casas, Josefina; Sanguinetti, Maurizio; Ghidoni, Riccardo; Borghi, Elisa; Signorelli, Paola.
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  • Caretti A; Biochemistry and Molecular Biology Laboratory, Health Sciences Department, University of Milan, San Paolo Hospital Medical School, Milan, Italy.
  • Torelli R; Institute of Microbiology, Cattolica del Sacro Cuore University, Rome, Italy.
  • Perdoni F; Microbiology Laboratory, Health Sciences Department, University of Milan, San Paolo Hospital Medical School, Milan, Italy.
  • Falleni M; Pathology Division, Health Sciences Department, University of Milan, San Paolo Hospital Medical School, Milan, Italy.
  • Tosi D; Pathology Division, Health Sciences Department, University of Milan, San Paolo Hospital Medical School, Milan, Italy.
  • Zulueta A; Biochemistry and Molecular Biology Laboratory, Health Sciences Department, University of Milan, San Paolo Hospital Medical School, Milan, Italy.
  • Casas J; Research Unit on BioActive Molecules, Department of Biomedicinal Chemistry, IQAC-CSIC, Barcelona, Spain.
  • Sanguinetti M; Institute of Microbiology, Cattolica del Sacro Cuore University, Rome, Italy.
  • Ghidoni R; Biochemistry and Molecular Biology Laboratory, Health Sciences Department, University of Milan, San Paolo Hospital Medical School, Milan, Italy.
  • Borghi E; Microbiology Laboratory, Health Sciences Department, University of Milan, San Paolo Hospital Medical School, Milan, Italy.
  • Signorelli P; Biochemistry and Molecular Biology Laboratory, Health Sciences Department, University of Milan, San Paolo Hospital Medical School, Milan, Italy. Electronic address: paola.signorelli@unimi.it.
Biochim Biophys Acta ; 1860(6): 1089-97, 2016 Jun.
Article en En | MEDLINE | ID: mdl-26922830
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aspergillus fumigatus / Ácidos Grasos Monoinsaturados / Ceramidas / Aspergilosis Pulmonar / Antiinflamatorios / Antifúngicos Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Año: 2016 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aspergillus fumigatus / Ácidos Grasos Monoinsaturados / Ceramidas / Aspergilosis Pulmonar / Antiinflamatorios / Antifúngicos Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Año: 2016 Tipo del documento: Article País de afiliación: Italia