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Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.
Hamelin, Lorraine; Lagarde, Julien; Dorothée, Guillaume; Leroy, Claire; Labit, Mickael; Comley, Robert A; de Souza, Leonardo Cruz; Corne, Helene; Dauphinot, Luce; Bertoux, Maxime; Dubois, Bruno; Gervais, Philippe; Colliot, Olivier; Potier, Marie Claude; Bottlaender, Michel; Sarazin, Marie.
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  • Hamelin L; Unit of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France UNIACT, NeuroSpin, Institut d'Imagerie Biomédicale, Direction des sciences du vivant, Commissariat à I'Energie Atomique
  • Lagarde J; Unit of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France.
  • Dorothée G; Immune System, Neuroinflammation and Neurodegenerative Diseases, Hôpital St-Antoine, INSERM, UMRS 938, CdR Saint-Antoine, F-75012, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, Hôpital Saint-Antoine, F-75012, Paris, France.
  • Leroy C; Laboratoire Imagerie Moléculaire In Vivo (IMIV), CEA, Inserm, Univ Paris Sud, CNRS, Université Paris Saclay, CEA-SHFJ, 91400 Orsay, France.
  • Labit M; CATI Multicenter Neuroimaging Platform, France.
  • Comley RA; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.
  • de Souza LC; Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Corne H; Department of Neurology, Salpêtrière Hospital, APHP, Paris, France.
  • Dauphinot L; Inserm, U1127, F-75013, Paris, France CNRS, UMR 7225 ICM, 75013, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France CNRS, U 75, Paris, France.
  • Bertoux M; Unit of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France Department of Clinical Neurosciences, University of Cambridge, UK.
  • Dubois B; Department of Neurology, Salpêtrière Hospital, APHP, Paris, France.
  • Gervais P; Laboratoire Imagerie Moléculaire In Vivo (IMIV), CEA, Inserm, Univ Paris Sud, CNRS, Université Paris Saclay, CEA-SHFJ, 91400 Orsay, France.
  • Colliot O; Department of Neurology, Salpêtrière Hospital, APHP, Paris, France Inserm, U1127, F-75013, Paris, France CNRS, UMR 7225 ICM, 75013, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France Inr
  • Potier MC; Inserm, U1127, F-75013, Paris, France CNRS, UMR 7225 ICM, 75013, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France CNRS, U 75, Paris, France.
  • Bottlaender M; UNIACT, NeuroSpin, Institut d'Imagerie Biomédicale, Direction des sciences du vivant, Commissariat à I'Energie Atomique, Gif-sur-Yvette, France Laboratoire Imagerie Moléculaire In Vivo (IMIV), CEA, Inserm, Univ Paris Sud, CNRS, Université Paris Saclay, CEA-SHFJ, 91400 Orsay, France.
  • Sarazin M; Unit of Memory and Language, Université Paris Descartes, Sorbonne Paris Cité, Centre de Psychiatrie et Neurosciences, INSERM UMR S894, Centre Hospitalier Sainte Anne, Paris, France m.sarazin@ch-sainte-anne.fr.
Brain ; 139(Pt 4): 1252-64, 2016 Apr.
Article en En | MEDLINE | ID: mdl-26984188
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Radioisótopos de Flúor / Microglía / Tomografía de Emisión de Positrones / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Año: 2016 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Radioisótopos de Flúor / Microglía / Tomografía de Emisión de Positrones / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Año: 2016 Tipo del documento: Article