A meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer.
Pancreatology
; 16(4): 605-14, 2016.
Article
en En
| MEDLINE
| ID: mdl-27237100
ABSTRACT
BACKGROUND:
K-ras codon 12 mutation is one of the earliest genetic changes in the development of pancreatic cancer (PC) and accurate detection of K-ras mutations is gaining increasing attention in the field of molecular diagnosis.METHODS:
Original research articles which evaluated the diagnostic accuracy of K-ras mutation detection in PC were selected. Data were presented as forest plots and summary receiver operating characteristic curve analysis was used to summarize the overall test performance.RESULTS:
We assessed 16 studies from 15 published articles. The pooled sensitivity and specificity were 59% (95%CI 54%-64%) and 87% (95%CI 84%-89%), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.13 (95%CI 2.73-6.25) and 0.42 (95%CI 0.32-0.56), respectively, and the pooled diagnostic odds ratio was 13.66 (95% CI 7.25-25.74).CONCLUSIONS:
Our results indicate that the analysis of K-ras mutations in pancreatic juice has a considerable diagnostic value in PC. Further studies with rigorous design, large sample size, and multi-regional co-operation are needed.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Jugo Pancreático
/
Neoplasias Pancreáticas
/
Biomarcadores de Tumor
/
Genes ras
/
Mutación
Tipo de estudio:
Diagnostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Pancreatology
Asunto de la revista:
ENDOCRINOLOGIA
/
GASTROENTEROLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
China