Phencyclidine (PCP) reduces the intensity of caffeine-induced convulsions in rats.
Life Sci
; 44(21): 1589-92, 1989.
Article
en En
| MEDLINE
| ID: mdl-2733542
ABSTRACT
The effects of phencyclidine (PCP) on the threshold and intensity of caffeine-induced convulsions in rats were examined. There was a dose-dependent effect of PCP on convulsion intensity with significant reduction in intensity at 4.0 and 8.0 mg/kg PCP. At 16.0 mg/kg PCP, convulsant intensity was reduced in 50% of subjects but potentiated to the point of death in the remaining 50%. PCP had no significant effect on threshold for caffeine-induced convulsions. These results suggest that PCP antagonizes caffeine-induced convulsions and further suggests that the mechanisms involved in onset of caffeine-induced convulsions and the decrease of convulsion intensity are pharmacologically dissociable.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenciclidina
/
Convulsiones
/
Cafeína
Límite:
Animals
Idioma:
En
Revista:
Life Sci
Año:
1989
Tipo del documento:
Article