Primary structure analysis of an integral membrane glycoprotein of the nuclear pore.
J Cell Biol
; 108(6): 2083-92, 1989 Jun.
Article
en En
| MEDLINE
| ID: mdl-2738089
ABSTRACT
The complete primary structure of an integral membrane glycoprotein of the nuclear pore was deduced from the cDNA sequence. The cDNA encodes a polypeptide of 204,205 D containing a 25-residue-long signal sequence, two hydrophobic segments that could function as transmembrane segments, and 13 potential N-linked oligosaccharide addition sites. Endoglycosidase H reduces the molecular mass by approximately 9 kD suggesting that not all of these 13 sites are used. We discuss possible models for the topology of this protein in the pore membrane as well as a possible role in the formation of pores and pore complexes.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Membrana Nuclear
Límite:
Animals
Idioma:
En
Revista:
J Cell Biol
Año:
1989
Tipo del documento:
Article