Applications of (19)F-NMR in Fragment-Based Drug Discovery.
Molecules
; 21(7)2016 Jul 16.
Article
en En
| MEDLINE
| ID: mdl-27438818
ABSTRACT
(19)F-NMR has proved to be a valuable tool in fragment-based drug discovery. Its applications include screening libraries of fluorinated fragments, assessing competition among elaborated fragments and identifying the binding poses of promising hits. By observing fluorine in both the ligand and the target protein, useful information can be obtained on not only the binding pose but also the dynamics of ligand-protein interactions. These applications of (19)F-NMR will be illustrated in this review with studies from our fragment-based drug discovery campaigns against protein targets in parasitic and infectious diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Relación Estructura-Actividad Cuantitativa
/
Descubrimiento de Drogas
/
Imagen por Resonancia Magnética con Fluor-19
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Australia