Bridging the Gap: Towards a cell-type specific understanding of neural circuits underlying fear behaviors.
Neurobiol Learn Mem
; 135: 27-39, 2016 Nov.
Article
en En
| MEDLINE
| ID: mdl-27470092
ABSTRACT
Fear and anxiety-related disorders are remarkably common and debilitating, and are often characterized by dysregulated fear responses. Rodent models of fear learning and memory have taken great strides towards elucidating the specific neuronal circuitries underlying the learning of fear responses. The present review addresses recent research utilizing optogenetic approaches to parse circuitries underlying fear behaviors. It also highlights the powerful advances made when optogenetic techniques are utilized in a genetically defined, cell-type specific, manner. The application of next-generation genetic and sequencing approaches in a cell-type specific context will be essential for a mechanistic understanding of the neural circuitry underlying fear behavior and for the rational design of targeted, circuit specific, pharmacologic interventions for the treatment and prevention of fear-related disorders.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conducta Animal
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Condicionamiento Clásico
/
Miedo
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Optogenética
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Amígdala del Cerebelo
Límite:
Animals
Idioma:
En
Revista:
Neurobiol Learn Mem
Asunto de la revista:
BIOLOGIA
/
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Año:
2016
Tipo del documento:
Article