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Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small-cell lung cancer.
Kinoshita, T; Muramatsu, R; Fujita, T; Nagumo, H; Sakurai, T; Noji, S; Takahata, E; Yaguchi, T; Tsukamoto, N; Kudo-Saito, C; Hayashi, Y; Kamiyama, I; Ohtsuka, T; Asamura, H; Kawakami, Y.
Afiliación
  • Kinoshita T; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Muramatsu R; Division of General Thoracic Surgery, Department of Surgery.
  • Fujita T; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Nagumo H; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Sakurai T; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Noji S; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Takahata E; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Yaguchi T; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Tsukamoto N; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Kudo-Saito C; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Hayashi Y; Division of Cellular Signaling, Institute for Advanced Medical Research.
  • Kamiyama I; Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
  • Ohtsuka T; Division of General Thoracic Surgery, Department of Surgery.
  • Asamura H; Division of General Thoracic Surgery, Department of Surgery.
  • Kawakami Y; Division of General Thoracic Surgery, Department of Surgery.
Ann Oncol ; 27(11): 2117-2123, 2016 11.
Article en En | MEDLINE | ID: mdl-27502728
ABSTRACT

BACKGROUND:

T-cell infiltration in tumors has been used as a prognostic tool in non-small-cell lung cancer (NSCLC). However, the influence of smoking habit and histological type on tumor-infiltrating lymphocytes (TILs) in NSCLC remains unclear. PATIENTS AND

METHODS:

We evaluated the prognostic significance of TILs (CD4+, CD8+, CD20+, and FOXP3+) according to histological type and smoking habit using automatic immunohistochemical staining and cell counting in 218 patients with NSCLC.

RESULTS:

In multivariate survival analyses of clinical, pathological, and immunological factors, a high ratio of FOXP3+ to CD4+ T cells (FOXP3/CD4) [hazard ratio (HR) 4.46, P < 0.01 for overall survival (OS); HR 1.96, P < 0.05 for recurrence-free survival (RFS)] and a low accumulation of CD20+ B cells (HR 2.45, P = 0.09 for OS; HR 2.86, P < 0.01 for RFS) were identified as worse prognostic factors in patients with adenocarcinoma (AD). In non-AD, a low number of CD8+ T cells were correlated with an unfavorable outcome (HR 7.69, P < 0.01 for OS; HR 3.57, P < 0.02 for RFS). Regarding smoking habit in AD, a high FOXP3/CD4 ratio was poorly prognostic with a smoking history (HR 5.21, P < 0.01 for OS; HR 2.38, P < 0.03 for RFS), whereas a low accumulation of CD20+ B cells (HR 4.54, P = 0.03 for OS; HR 2.94, P < 0.01 for RFS) was confirmed as an unfavorable factor in non-smokers with AD.

CONCLUSIONS:

A low number of CD8+ T cells in non-AD, a high FOXP3/CD4 ratio in smokers with AD, and a low number of CD20+ B cells in non-smokers with AD were identified as independent unfavorable prognostic factors in resected NSCLC. Evaluating the influence of histological type and smoking habit on the immunological environment may lead to the establishment of immunological diagnosis and appropriate individualized immunotherapy for NSCLC.
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pronóstico / Linfocitos Infiltrantes de Tumor / Carcinoma de Pulmón de Células no Pequeñas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article
Buscar en Google
Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pronóstico / Linfocitos Infiltrantes de Tumor / Carcinoma de Pulmón de Células no Pequeñas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article