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Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.
Beale, Gary; Haagensen, Emma J; Thomas, Huw D; Wang, Lan-Zhen; Revill, Charlotte H; Payne, Sara L; Golding, Bernard T; Hardcastle, Ian R; Newell, David R; Griffin, Roger J; Cano, Celine.
Afiliación
  • Beale G; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.
  • Haagensen EJ; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.
  • Thomas HD; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.
  • Wang LZ; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.
  • Revill CH; Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Bedson Building, Newcastle NE1 7RU, UK.
  • Payne SL; Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Bedson Building, Newcastle NE1 7RU, UK.
  • Golding BT; Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Bedson Building, Newcastle NE1 7RU, UK.
  • Hardcastle IR; Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Bedson Building, Newcastle NE1 7RU, UK.
  • Newell DR; Newcastle Cancer Centre, Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.
  • Griffin RJ; Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Bedson Building, Newcastle NE1 7RU, UK.
  • Cano C; Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Bedson Building, Newcastle NE1 7RU, UK.
Br J Cancer ; 115(6): 682-90, 2016 09 06.
Article en En | MEDLINE | ID: mdl-27529512

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Neoplasias Colorrectales / Adenocarcinoma / Inhibidores de Proteínas Quinasas / Quinasa 2 Dependiente de la Ciclina / Terapia Molecular Dirigida / Inhibidores de las Quinasa Fosfoinosítidos-3 / Proteínas de Neoplasias Tipo de estudio: Clinical_trials Límite: Animals / Humans Idioma: En Revista: Br J Cancer Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Neoplasias Colorrectales / Adenocarcinoma / Inhibidores de Proteínas Quinasas / Quinasa 2 Dependiente de la Ciclina / Terapia Molecular Dirigida / Inhibidores de las Quinasa Fosfoinosítidos-3 / Proteínas de Neoplasias Tipo de estudio: Clinical_trials Límite: Animals / Humans Idioma: En Revista: Br J Cancer Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido