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A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.
Cuadrado-Tejedor, Mar; Garcia-Barroso, Carolina; Sánchez-Arias, Juan A; Rabal, Obdulia; Pérez-González, Marta; Mederos, Sara; Ugarte, Ana; Franco, Rafael; Segura, Victor; Perea, Gertrudis; Oyarzabal, Julen; Garcia-Osta, Ana.
Afiliación
  • Cuadrado-Tejedor M; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Garcia-Barroso C; Anatomy Department, School of Medicine, University of Navarra, Pamplona, Spain.
  • Sánchez-Arias JA; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Rabal O; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Pérez-González M; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Mederos S; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Ugarte A; Cajal Institute, CSIC, Madrid, Spain.
  • Franco R; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Segura V; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Perea G; Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain.
  • Oyarzabal J; Bioinformatics Unit, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
  • Garcia-Osta A; Cajal Institute, CSIC, Madrid, Spain.
Neuropsychopharmacology ; 42(2): 524-539, 2017 01.
Article en En | MEDLINE | ID: mdl-27550730
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinonas / Inhibidores de Histona Desacetilasas / Inhibidores de Fosfodiesterasa 5 / Enfermedad de Alzheimer / Hipocampo / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Neuropsychopharmacology Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinonas / Inhibidores de Histona Desacetilasas / Inhibidores de Fosfodiesterasa 5 / Enfermedad de Alzheimer / Hipocampo / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Neuropsychopharmacology Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: España