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Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.
Cioffi, Christopher L; Liu, Shuang; Wolf, Mark A; Guzzo, Peter R; Sadalapure, Kashinath; Parthasarathy, Visweswaran; Loong, David T J; Maeng, Jun-Ho; Carulli, Edmund; Fang, Xiao; Karunakaran, Kalesh; Matta, Lakshman; Choo, Sok Hui; Panduga, Shailijia; Buckle, Ronald N; Davis, Randall N; Sakwa, Samuel A; Gupta, Priya; Sargent, Bruce J; Moore, Nicholas A; Luche, Michele M; Carr, Grant J; Khmelnitsky, Yuri L; Ismail, Jiffry; Chung, Mark; Bai, Mei; Leong, Wei Yee; Sachdev, Nidhi; Swaminathan, Srividya; Mhyre, Andrew J.
Afiliación
  • Cioffi CL; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Liu S; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Wolf MA; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Guzzo PR; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Sadalapure K; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Parthasarathy V; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Loong DT; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Maeng JH; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Carulli E; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Fang X; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Karunakaran K; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Matta L; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Choo SH; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Panduga S; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Buckle RN; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Davis RN; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Sakwa SA; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Gupta P; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Sargent BJ; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Moore NA; Department of Medicinal Chemistry, AMRI , East Campus, 3 University Place, Rensselaer, New York 12144, United States.
  • Luche MM; Bothell Research Center, AMRI , 22215 26th Ave SE, Bothell, Washington 98021-4425, United States.
  • Carr GJ; Bothell Research Center, AMRI , 22215 26th Ave SE, Bothell, Washington 98021-4425, United States.
  • Khmelnitsky YL; Drug Metabolism and Pharmacokinetics, AMRI , East Campus, 17 University Place, Rensselaer, New York 12144, United States.
  • Ismail J; Drug Metabolism and Pharmacokinetics, AMRI , East Campus, 17 University Place, Rensselaer, New York 12144, United States.
  • Chung M; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Bai M; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Leong WY; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Sachdev N; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Swaminathan S; Discovery Research and Development Chemistry, Singapore Research Center, AMRI , 61 Science Park Road, Science Park III, 117525, Singapore.
  • Mhyre AJ; Bothell Research Center, AMRI , 22215 26th Ave SE, Bothell, Washington 98021-4425, United States.
J Med Chem ; 59(18): 8473-94, 2016 Sep 22.
Article en En | MEDLINE | ID: mdl-27559615
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzamidas / Proteínas de Transporte de Glicina en la Membrana Plasmática Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzamidas / Proteínas de Transporte de Glicina en la Membrana Plasmática Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos