Pathway Design, Engineering, and Optimization.
Adv Biochem Eng Biotechnol
; 162: 77-116, 2018.
Article
en En
| MEDLINE
| ID: mdl-27629378
ABSTRACT
The microbial metabolic versatility found in nature has inspired scientists to create microorganisms capable of producing value-added compounds. Many endeavors have been made to transfer and/or combine pathways, existing or even engineered enzymes with new function to tractable microorganisms to generate new metabolic routes for drug, biofuel, and specialty chemical production. However, the success of these pathways can be impeded by different complications from an inherent failure of the pathway to cell perturbations. Pursuing ways to overcome these shortcomings, a wide variety of strategies have been developed. This chapter will review the computational algorithms and experimental tools used to design efficient metabolic routes, and construct and optimize biochemical pathways to produce chemicals of high interest.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Bacterias
/
Algoritmos
/
Simulación por Computador
/
Ingeniería Metabólica
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Adv Biochem Eng Biotechnol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos