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Thin-Section CT Features of Idiopathic Pulmonary Fibrosis Correlated with Micro-CT and Histologic Analysis.
Mai, Cindy; Verleden, Stijn E; McDonough, John E; Willems, Stijn; De Wever, Walter; Coolen, Johan; Dubbeldam, Adriana; Van Raemdonck, Dirk E; Verbeken, Eric K; Verleden, Geert M; Hogg, James C; Vanaudenaerde, Bart M; Wuyts, Wim A; Verschakelen, Johny A.
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  • Mai C; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Verleden SE; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • McDonough JE; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Willems S; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • De Wever W; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Coolen J; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Dubbeldam A; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Van Raemdonck DE; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Verbeken EK; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Verleden GM; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Hogg JC; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Vanaudenaerde BM; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Wuyts WA; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
  • Verschakelen JA; From the Department of Radiology (C.M., W.D.W., J.C., A.D., J.A.V.), Leuven Lung Transplant Unit (S.E.V., J.E.M., S.W., D.E.V.R., G.M.V., B.M.V., W.A.W.), and Department of Pathology (E.K.V.), UZ Leuven, Herestraat 49, 3000 Leuven, Belgium; and University of British Columbia James Hogg Research Cent
Radiology ; 283(1): 252-263, 2017 04.
Article en En | MEDLINE | ID: mdl-27715655
Purpose To elucidate the underlying lung changes responsible for the computed tomographic (CT) features of idiopathic pulmonary fibrosis (IPF) and to gain insight into the way IPF proceeds through the lungs and progresses over time. Materials and Methods Micro-CT studies of tissue cores obtained from explant lungs were examined and were correlated 1:1 with a CT study obtained immediately before transplantation. Samples for histologic analysis were obtained from selected cores. Results In areas with no or minimal abnormalities on CT images, small areas of increased attenuation located in or near the interlobular septa can be seen on micro-CT studies. In more involved lung areas, the number of opacities increases and opacities enlarge and approach each other along the interlobular septa, causing a fine reticular pattern on CT images. Simultaneously, air-containing structures in and around these opacities arise, corresponding with small cysts on CT images. Honeycombing is caused by a progressive increase in the number and size of these cystic structures and tissue opacities that gradually extend toward the centrilobular region and finally replace the entire lobule. At histologic analysis, the small islands of increased attenuation very likely correspond with fibroblastic foci. Near these fibroblastic foci, an abnormal adjacency of alveolar walls was seen, suggesting alveolar collapse. In later stages, normal lung tissue is replaced by a large amount of young collagen, as seen in patients with advanced fibrosis. Conclusion Fibrosis and cyst formation in patients with IPF seem to start at the periphery of the pulmonary lobule and progressively extend toward the core of this anatomic lung unit. Evidence was found that alveolar collapse might already be present in an early stage when there is only little pulmonary fibrosis. © RSNA, 2016.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Fibrosis Pulmonar Idiopática Límite: Humans / Male / Middle aged Idioma: En Revista: Radiology Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tomografía Computarizada por Rayos X / Fibrosis Pulmonar Idiopática Límite: Humans / Male / Middle aged Idioma: En Revista: Radiology Año: 2017 Tipo del documento: Article