The Impact of Inspiratory Flow Rate on Drug Delivery to the Lungs with Dry Powder Inhalers.
Pharm Res
; 34(3): 507-528, 2017 03.
Article
en En
| MEDLINE
| ID: mdl-27738953
ABSTRACT
Current marketed dry powder inhalers utilize the energy from patient inspiration to fluidize and disperse bulk powder agglomerates into respirable particles. Variations in patient inspiratory flow profiles can lead to marked differences in total lung dose (TLD), and ultimately patient outcomes for an inhaled therapeutic. The present review aims to quantitate the flow rate dependence in TLD observed for a number of drug/device combinations using a new metric termed the Q index. With this data in hand, the review explores key attributes in the design of the formulation and device that impact flow rate dependence. The review also proposes alternative in vitro methods to assess flow rate dependence that more closely align with in vivo observations. Finally, the impact of variations in flow rate on lung function for inhaled bronchodilators is summarized.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Broncodilatadores
/
Enfermedad Pulmonar Obstructiva Crónica
/
Inhaladores de Polvo Seco
Límite:
Humans
Idioma:
En
Revista:
Pharm Res
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos