Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway.
Oncotarget
; 8(1): 1541-1554, 2017 Jan 03.
Article
en En
| MEDLINE
| ID: mdl-27903975
ABSTRACT
Cortactin (CTTN) is overexpressed in various tumors, including head and neck squamous cell carcinoma and colorectal cancer (CRC), and can serve as a biomarker of cancer metastasis. We observed that CTTN promotes cancer cell proliferation in vitro and increases CRC tumor xenograft growth in vivo. CTTN expression increases EGFR protein levels and enhances the activation of the MAPK signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR by suppressing the coupling of c-Cbl with EGFR. CoIP experiments indicate CTTN can interact with c-Cbl in CRC cells. These results demonstrate that CTTN promotes the proliferation of CRC cells and suppresses the degradation of EGFR.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
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Sistema de Señalización de MAP Quinasas
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Cortactina
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Receptores ErbB
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Oncotarget
Año:
2017
Tipo del documento:
Article