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Prognostic assessment of stable coronary artery disease as determined by coronary computed tomography angiography: a Danish multicentre cohort study.
Nielsen, Lene H; Bøtker, Hans Erik; Sørensen, Henrik T; Schmidt, Morten; Pedersen, Lars; Sand, Niels Peter; Jensen, Jesper M; Steffensen, Flemming H; Tilsted, Hans Henrik; Bøttcher, Morten; Diederichsen, Axel; Lambrechtsen, Jess; Kristensen, Lone D; Øvrehus, Kristian A; Mickley, Hans; Munkholm, Henrik; Gøtzsche, Ole; Husain, Majed; Knudsen, Lars L; Nørgaard, Bjarne L.
Afiliación
  • Nielsen LH; Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark.
  • Bøtker HE; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Sørensen HT; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
  • Schmidt M; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
  • Pedersen L; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
  • Sand NP; Department of Cardiology, Hospital of South West Jutland, Esbjerg, Denmark.
  • Jensen JM; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Steffensen FH; Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark.
  • Tilsted HH; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
  • Bøttcher M; Department of Cardiology, Regional Hospital Herning, Herning, Denmark.
  • Diederichsen A; Department of Cardiology, Odense University Hospital, Denmark.
  • Lambrechtsen J; Department of Cardiology, Svendborg Hospital, Denmark.
  • Kristensen LD; Department of Cardiology, Regional Hospital Silkeborg, Silkeborg, Denmark.
  • Øvrehus KA; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Mickley H; Department of Cardiology, Odense University Hospital, Denmark.
  • Munkholm H; Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark.
  • Gøtzsche O; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
  • Husain M; Department of Cardiology, Hospital of South West Jutland, Esbjerg, Denmark.
  • Knudsen LL; Department of Cardiology, Regional Hospital Herning, Herning, Denmark.
  • Nørgaard BL; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Eur Heart J ; 38(6): 413-421, 2017 02 07.
Article en En | MEDLINE | ID: mdl-27941018
Aims: To examine the 3.5 year prognosis of stable coronary artery disease (CAD) as assessed by coronary computed tomography angiography (CCTA) in real-world clinical practice, overall and within subgroups of patients according to age, sex, and comorbidity. Methods and results: This cohort study included 16,949 patients (median age 57 years; 57% women) with new-onset symptoms suggestive of CAD, who underwent CCTA between January 2008 and December 2012. The endpoint was a composite of late coronary revascularization procedure >90 days after CCTA, myocardial infarction, and all-cause death. The Kaplan-Meier estimator was used to compute 91 day to 3.5 year risk according to the CAD severity. Comparisons between patients with and without CAD were based on Cox-regression adjusted for age, sex, comorbidity, cardiovascular risk factors, concomitant cardiac medications, and post-CCTA treatment within 90 days. The composite endpoint occurred in 486 patients. Risk of the composite endpoint was 1.5% for patients without CAD, 6.8% for obstructive CAD, and 15% for three-vessel/left main disease. Compared with patients without CAD, higher relative risk of the composite endpoint was observed for non-obstructive CAD [hazard ratio (HR): 1.28; 95% confidence interval (CI): 1.01-1.63], obstructive one-vessel CAD (HR: 1.83; 95% CI: 1.37-2.44), two-vessel CAD (HR: 2.97; 95% CI: 2.09-4.22), and three-vessel/left main CAD (HR: 4.41; 95% CI :2.90-6.69). The results were consistent in strata of age, sex, and comorbidity. Conclusion: Coronary artery disease determined by CCTA in real-world practice predicts the 3.5 year composite risk of late revascularization, myocardial infarction, and all-cause death across different groups of age, sex, or comorbidity burden.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur Heart J Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur Heart J Año: 2017 Tipo del documento: Article País de afiliación: Dinamarca