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Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen.
Cox, Jonathan A G; Mugumbate, Grace; Del Peral, Laura Vela-Glez; Jankute, Monika; Abrahams, Katherine A; Jervis, Peter; Jackenkroll, Stefan; Perez, Arancha; Alemparte, Carlos; Esquivias, Jorge; Lelièvre, Joël; Ramon, Fernando; Barros, David; Ballell, Lluis; Besra, Gurdyal S.
Afiliación
  • Cox JA; Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
  • Mugumbate G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, CB10 1SD.
  • Del Peral LV; Molecular Discovery Research, GlaxoSmithKline, Santiago Grisolia 4, 28760 Tres Cantos, Madrid, Spain.
  • Jankute M; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Abrahams KA; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Jervis P; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Jackenkroll S; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
  • Perez A; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
  • Alemparte C; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
  • Esquivias J; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
  • Lelièvre J; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
  • Ramon F; Molecular Discovery Research, GlaxoSmithKline, Santiago Grisolia 4, 28760 Tres Cantos, Madrid, Spain.
  • Barros D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
  • Ballell L; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
  • Besra GS; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Sci Rep ; 6: 38986, 2016 12 16.
Article en En | MEDLINE | ID: mdl-27982051
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Inhibidores Enzimáticos / IMP Deshidrogenasa / Mycobacterium tuberculosis / Antituberculosos Tipo de estudio: Prognostic_studies Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Inhibidores Enzimáticos / IMP Deshidrogenasa / Mycobacterium tuberculosis / Antituberculosos Tipo de estudio: Prognostic_studies Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido