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Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.
Yang, Michael G; Xiao, Zili; Dhar, T G Murali; Xiao, Hai-Yun; Gilmore, John L; Marcoux, David; Xie, Jenny H; McIntyre, Kim W; Taylor, Tracy L; Borowski, Virna; Heimrich, Elizabeth; Li, Yu-Wen; Feng, Jianlin; Fernandes, Alda; Yang, Zheng; Balimane, Praveen; Marino, Anthony M; Cornelius, Georgia; Warrack, Bethanne M; Mathur, Arvind; Wu, Dauh-Rurng; Li, Peng; Gupta, Anuradha; Pragalathan, Bala; Shen, Ding Ren; Cvijic, Mary Ellen; Lehman-McKeeman, Lois D; Salter-Cid, Luisa; Barrish, Joel C; Carter, Percy H; Dyckman, Alaric J.
Afiliación
  • Yang MG; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Xiao Z; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Dhar TG; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Xiao HY; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Gilmore JL; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Marcoux D; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Xie JH; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • McIntyre KW; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Taylor TL; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Borowski V; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Heimrich E; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Li YW; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Feng J; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Fernandes A; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Yang Z; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Balimane P; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Marino AM; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Cornelius G; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Warrack BM; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Mathur A; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Wu DR; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Li P; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Gupta A; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Pragalathan B; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Shen DR; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Cvijic ME; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Lehman-McKeeman LD; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Salter-Cid L; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Barrish JC; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Carter PH; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
  • Dyckman AJ; Research and Development, Bristol-Myers Squibb Company , Princeton, New Jersey 08543-4000, United States.
J Med Chem ; 59(24): 11138-11147, 2016 12 22.
Article en En | MEDLINE | ID: mdl-28002964
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de Lisoesfingolípidos / Encefalomielitis Autoinmune Experimental / Naftalenos Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de Lisoesfingolípidos / Encefalomielitis Autoinmune Experimental / Naftalenos Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos