The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of <i>var</i> Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1.

Mkumbaye, Sixbert I; Wang, Christian W; Lyimo, Eric; Jespersen, Jakob S; Manjurano, Alphaxard; Mosha, Jacklin; Kavishe, Reginald A; Mwakalinga, Steven B; Minja, Daniel T R; Lusingu, John P; Theander, Thor G; Lavstsen, Thomas

The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1.

Mkumbaye, Sixbert I; Wang, Christian W; Lyimo, Eric; Jespersen, Jakob S; Manjurano, Alphaxard; Mosha, Jacklin; Kavishe, Reginald A; Mwakalinga, Steven B; Minja, Daniel T R; Lusingu, John P; Theander, Thor G; Lavstsen, Thomas.

Afiliación

Mkumbaye SI; Kilimanjaro Christian Medical University College and Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
Wang CW; Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Lyimo E; National Institute for Medical Research, Mwanza Research Centre, Mwanza, Tanzania.
Jespersen JS; Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Manjurano A; National Institute for Medical Research, Mwanza Research Centre, Mwanza, Tanzania.
Mosha J; National Institute for Medical Research, Mwanza Research Centre, Mwanza, Tanzania.
Kavishe RA; Kilimanjaro Christian Medical University College and Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
Mwakalinga SB; Kilimanjaro Christian Medical University College and Kilimanjaro Clinical Research Institute, Moshi, Tanzania.
Minja DTR; National Institute for Medical Research, Tanga Research Centre, Tanga, Tanzania.
Lusingu JP; National Institute for Medical Research, Tanga Research Centre, Tanga, Tanzania.
Theander TG; Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Lavstsen T; Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark thomasl@sund.ku.dk.

Infect Immun ; 85(4)2017 04.

Article en En | MEDLINE | ID: mdl-28138022

Asunto(s)

Regulación de la Expresión Génica; Malaria Falciparum/parasitología; Plasmodium falciparum/genética; Proteínas Protozoarias/genética; Transcripción Genética; Biomarcadores; Niño; Preescolar; Humanos; Lactante; Malaria Falciparum/diagnóstico; Malaria Falciparum/inmunología; Plasmodium falciparum/inmunología; Dominios y Motivos de Interacción de Proteínas; Proteínas Protozoarias/química; Índice de Severidad de la Enfermedad; Tanzanía

Palabras clave

PfEMP1; Plasmodium falciparum; antigenic variation; gene expression; malaria

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Transcripción Genética / Proteínas Protozoarias / Regulación de la Expresión Génica / Malaria Falciparum Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: Infect Immun Año: 2017 Tipo del documento: Article País de afiliación: Tanzania

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