Making Mouse Models That Reflect Human Immune Responses.
Trends Immunol
; 38(3): 181-193, 2017 03.
Article
en En
| MEDLINE
| ID: mdl-28161189
ABSTRACT
Humans are infected with a variety of acute and chronic pathogens over the course of their lives, and pathogen-driven selection has shaped the immune system of humans. The same is likely true for mice. However, laboratory mice we use for most biomedical studies are bred in ultra-hygienic environments, and are kept free of specific pathogens. We review recent studies that indicate that pathogen infections are important for the basal level of activation and the function of the immune system. Consideration of these environmental exposures of both humans and mice can potentially improve mouse models of human disease.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Modelos Animales de Enfermedad
/
Sistema Inmunológico
/
Inmunidad
/
Enfermedades del Sistema Inmune
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos