Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.

Lupu, Daniel S; Orozco, Luz D; Wang, Ying; Cullen, John M; Pellegrini, Matteo; Zeisel, Steven H

Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.

Lupu, Daniel S; Orozco, Luz D; Wang, Ying; Cullen, John M; Pellegrini, Matteo; Zeisel, Steven H.

Afiliación

Lupu DS; Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA.
Orozco LD; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA.
Wang Y; Department of Clinical Nutrition, School of Medicine, Xin Hua Hospital, Shanghai Jiao Tong University, Shanghai, China.
Cullen JM; North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina, USA.
Pellegrini M; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, California, USA.
Zeisel SH; Department of Nutrition, Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA; steven_zeisel@unc.edu.

FASEB J ; 31(5): 2090-2103, 2017 05.

Article en En | MEDLINE | ID: mdl-28179424

Asunto(s)

Metilación de ADN; ADN/metabolismo; Ácido Fólico/metabolismo; Hígado/metabolismo; Lesiones Precancerosas/metabolismo; Receptores de Trombina/metabolismo; Proteínas Activadoras de ras GTPasa/metabolismo; Animales; Betaína-Homocisteína S-Metiltransferasa/deficiencia; Betaína-Homocisteína S-Metiltransferasa/metabolismo; Metilación de ADN/fisiología; Glutatión Transferasa/metabolismo; Ratones Endogámicos C57BL; Ratones Noqueados; Receptores de Trombina/genética; Proteínas Activadoras de ras GTPasa/genética

Palabras clave

betaine; epigenetics; folate; methylome

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lesiones Precancerosas / ADN / Receptores de Trombina / Metilación de ADN / Proteínas Activadoras de ras GTPasa / Ácido Fólico / Hígado Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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