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Discovery of phenyl acetamides as potent and selective GPR119 agonists.
Zhu, Cheng; Wang, Liping; Zhu, Yuping; Guo, Zack Zhiqiang; Liu, Ping; Hu, Zhiyong; Szewczyk, Jason W; Kang, Ling; Chicchi, Gary; Ehrhardt, Anka; Woods, Andrea; Seo, Toru; Woods, Morgan; van Heek, Margaret; Dingley, Karen H; Pang, Jianmei; Salituro, Gino M; Powell, Joyce; Terebetski, Jenna L; Hornak, Viktor; Campeau, Louis-Charles; Orr, Robert K; Ujjainwalla, Feroze; Miller, Michael; Stamford, Andrew; Wood, Harold B; Kowalski, Timothy; Nargund, Ravi P; Edmondson, Scott D.
Afiliación
  • Zhu C; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: cheng.zhu@merck.com.
  • Wang L; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Zhu Y; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Guo ZZ; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Liu P; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Hu Z; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Szewczyk JW; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Kang L; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Chicchi G; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Ehrhardt A; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Woods A; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Seo T; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Woods M; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • van Heek M; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Dingley KH; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Pang J; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Salituro GM; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Powell J; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Terebetski JL; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Hornak V; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Campeau LC; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Orr RK; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Ujjainwalla F; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Miller M; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Stamford A; Early Development and Discovery Sciences, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA.
  • Wood HB; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Kowalski T; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Nargund RP; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
  • Edmondson SD; Early Development and Discovery Sciences, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Bioorg Med Chem Lett ; 27(5): 1124-1128, 2017 03 01.
Article en En | MEDLINE | ID: mdl-28185720
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G / Acetamidas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores Acoplados a Proteínas G / Acetamidas Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article