Advantages and Some Remaining Challenges in Hereditary Gastrointestinal Cancer Panel Testing.
Clin Transl Gastroenterol
; 8(5): e92, 2017 May 11.
Article
en En
| MEDLINE
| ID: mdl-28492537
ABSTRACT
Colorectal cancer affects 1 in 20 men and women in their lifetime. About 30% of these cases have been shown to be familial while only about 5% are associated with a highly penetrant hereditary colon cancer syndrome. In many familial cases, however, no mutation in the commonly implicated CRC genes is found. With the development of next-generation sequencing, testing laboratories are now able to offer hereditary gastrointestinal panel testing, which allows for the simultaneous sequencing of a much broader set of genes associated with CRC. We discuss the advantages and disadvantages of such testing to inform best clinical practice.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Clin Transl Gastroenterol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos