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Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors.
Dalvi, Maithili P; Wang, Lei; Zhong, Rui; Kollipara, Rahul K; Park, Hyunsil; Bayo, Juan; Yenerall, Paul; Zhou, Yunyun; Timmons, Brenda C; Rodriguez-Canales, Jaime; Behrens, Carmen; Mino, Barbara; Villalobos, Pamela; Parra, Edwin R; Suraokar, Milind; Pataer, Apar; Swisher, Stephen G; Kalhor, Neda; Bhanu, Natarajan V; Garcia, Benjamin A; Heymach, John V; Coombes, Kevin; Xie, Yang; Girard, Luc; Gazdar, Adi F; Kittler, Ralf; Wistuba, Ignacio I; Minna, John D; Martinez, Elisabeth D.
Afiliación
  • Dalvi MP; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang L; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Zhong R; Department of Clinical Science, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Kollipara RK; Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Park H; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Bayo J; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Yenerall P; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Eugene McDermott Center for Human Growth and Development, The U
  • Zhou Y; Department of Clinical Science, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Timmons BC; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Rodriguez-Canales J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Behrens C; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Mino B; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Villalobos P; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Parra ER; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Suraokar M; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Pataer A; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Swisher SG; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kalhor N; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Bhanu NV; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Garcia BA; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Heymach JV; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Coombes K; Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
  • Xie Y; Department of Clinical Science, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Girard L; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Gazdar AF; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Kittler R; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Eugene McDermott Center for Human Growth and Development, The University of Texas S
  • Wistuba II; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Minna JD; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwester
  • Martinez ED; Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, The University of Texas Southwester
Cell Rep ; 19(8): 1669-1684, 2017 05 23.
Article en En | MEDLINE | ID: mdl-28538184
Asunto(s)
Hidrocarburos Aromáticos con Puentes/uso terapéutico; Carboplatino/uso terapéutico; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Resistencia a Antineoplásicos; Inhibidores Enzimáticos/uso terapéutico; Histona Demetilasas con Dominio de Jumonji/antagonistas & inhibidores; Neoplasias Pulmonares/tratamiento farmacológico; Taxoides/uso terapéutico; Aminopiridinas/efectos adversos; Aminopiridinas/farmacología; Aminopiridinas/uso terapéutico; Animales; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Benzazepinas/efectos adversos; Benzazepinas/farmacología; Benzazepinas/uso terapéutico; Hidrocarburos Aromáticos con Puentes/farmacología; Carboplatino/farmacología; Carcinoma de Pulmón de Células no Pequeñas/genética; Carcinoma de Pulmón de Células no Pequeñas/patología; Línea Celular Tumoral; Supervivencia sin Enfermedad; Resistencia a Antineoplásicos/efectos de los fármacos; Resistencia a Antineoplásicos/genética; Inhibidores Enzimáticos/farmacología; Perfilación de la Expresión Génica; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Histonas/metabolismo; Humanos; Hidrazonas/efectos adversos; Hidrazonas/farmacología; Hidrazonas/uso terapéutico; Histona Demetilasas con Dominio de Jumonji/metabolismo; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patología; Metilación; Ratones; Terapia Neoadyuvante; Pirimidinas/efectos adversos; Pirimidinas/farmacología; Pirimidinas/uso terapéutico; Taxoides/farmacología; Transcripción Genética/efectos de los fármacos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hidrocarburos Aromáticos con Puentes / Carboplatino / Carcinoma de Pulmón de Células no Pequeñas / Resistencia a Antineoplásicos / Taxoides / Inhibidores Enzimáticos / Histona Demetilasas con Dominio de Jumonji / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hidrocarburos Aromáticos con Puentes / Carboplatino / Carcinoma de Pulmón de Células no Pequeñas / Resistencia a Antineoplásicos / Taxoides / Inhibidores Enzimáticos / Histona Demetilasas con Dominio de Jumonji / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Rep Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos