Antivitamin B<sub>12</sub> Inhibition of the Human B<sub>12</sub> -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate.

Ruetz, Markus; Shanmuganathan, Aranganathan; Gherasim, Carmen; Karasik, Agnes; Salchner, Robert; Kieninger, Christoph; Wurst, Klaus; Banerjee, Ruma; Koutmos, Markos; Kräutler, Bernhard

Antivitamin B₁₂ Inhibition of the Human B₁₂ -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate.

Ruetz, Markus; Shanmuganathan, Aranganathan; Gherasim, Carmen; Karasik, Agnes; Salchner, Robert; Kieninger, Christoph; Wurst, Klaus; Banerjee, Ruma; Koutmos, Markos; Kräutler, Bernhard.

Afiliación

Ruetz M; Institute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, 6020, Innsbruck, Austria.
Shanmuganathan A; University of Michigan Medical School, Ann Arbor, USA.
Gherasim C; Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, USA.
Karasik A; University of Michigan Medical School, Ann Arbor, USA.
Salchner R; Current address: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Kieninger C; Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, USA.
Wurst K; Institute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, 6020, Innsbruck, Austria.
Banerjee R; Current address: Watercryst GmbH & Co, Kematen, Austria.
Koutmos M; Institute of Organic Chemistry and Center for Molecular Biosciences, University of Innsbruck, 6020, Innsbruck, Austria.
Kräutler B; Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Austria.

Angew Chem Int Ed Engl ; 56(26): 7387-7392, 2017 06 19.

Article en En | MEDLINE | ID: mdl-28544088

Asunto(s)

Glutatión/química; Vitamina B 12/antagonistas & inhibidores; Dominio Catalítico; Cristalografía por Rayos X; Flúor/química; Humanos; Hidrólisis; Cinética; Modelos Moleculares; Estructura Molecular; Análisis Espectral/métodos; Especificidad por Sustrato; Temperatura; Vitamina B 12/química; Vitamina B 12/farmacología

Palabras clave

antivitamins; enzyme inhibitors; glutathione; protein crystallography; vitaminâB12

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vitamina B 12 / Glutatión Límite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Año: 2017 Tipo del documento: Article País de afiliación: Austria

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google