E6 proteins of α and ß cutaneous HPV types differ in their ability to potentiate Wnt signaling.
Virology
; 509: 11-22, 2017 09.
Article
en En
| MEDLINE
| ID: mdl-28586650
ABSTRACT
We recently showed that E6 protein of human papillomavirus (HPV) 16, a mucosal high-risk α-PV type, can potentiate Wnt/ß-catenin/TCF signaling. Here we investigated the transcriptional activities of E6 proteins of cutaneous HPV types from the ß and α genera. Results from reporter-gene assays showed that similar to HPV16 E6, E6 of HPV10, a cutaneous α-HPV type that is prevalent in skin warts, efficiently enhances and stimulates Wnt/ß-catenin/TCF transcription. HPV10 E6 also effectively elevated the expression levels of ß-catenin and promoted its nuclear accumulation. E6 proteins of ß-HPV types 8, 24, 38 and 49, which are prevalent in skin cancer, exhibited lower activities in all tested functions. The differences in activity correlated with E6's competence to interact with the ubiquitin ligase E6AP. This study reveals a role for E6 proteins of diverse cutaneous HPV types in potentiation of Wnt/ß-catenin signaling, irrespective of their carcinogenic potential.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Papillomaviridae
/
Neoplasias Cutáneas
/
Verrugas
/
Proteínas Oncogénicas Virales
/
Interacciones Huésped-Patógeno
/
Vía de Señalización Wnt
Límite:
Humans
Idioma:
En
Revista:
Virology
Año:
2017
Tipo del documento:
Article