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Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms.
Cattane, Nadia; Rossi, Roberta; Lanfredi, Mariangela; Cattaneo, Annamaria.
Afiliación
  • Cattane N; Biological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, via Pilastroni 4, Brescia, Italy.
  • Rossi R; Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, via Pilastroni 4, Brescia, Italy.
  • Lanfredi M; Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, via Pilastroni 4, Brescia, Italy.
  • Cattaneo A; Biological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli, via Pilastroni 4, Brescia, Italy. annamaria.cattaneo@kcl.ac.uk.
BMC Psychiatry ; 17(1): 221, 2017 06 15.
Article en En | MEDLINE | ID: mdl-28619017
ABSTRACT

BACKGROUND:

According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability.

DISCUSSION:

We prove the role of alterations in Hypothalamic-Pituitary-Adrenal (HPA) axis, in neurotrasmission, in the endogenous opioid system and in neuroplasticity in the childhood trauma-associated vulnerability to develop BPD; we also confirm the presence of morphological changes in several BPD brain areas and in particular in those involved in stress response. Not so many studies are available on epigenetic changes in BPD patients, although these mechanisms are widely investigated in relation to stress-related disorders. A better comprehension of the biological and epigenetic mechanisms, affected by childhood trauma and altered in BPD patients, could allow to identify "at high risk" subjects and to prevent or minimize the development of the disease later in life.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema Hipófiso-Suprarrenal / Trastorno de Personalidad Limítrofe / Sistema Hipotálamo-Hipofisario Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: BMC Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2017 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema Hipófiso-Suprarrenal / Trastorno de Personalidad Limítrofe / Sistema Hipotálamo-Hipofisario Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Child / Female / Humans / Pregnancy Idioma: En Revista: BMC Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2017 Tipo del documento: Article País de afiliación: Italia