miRNAs in B Cell Development and Lymphomagenesis.
Trends Mol Med
; 23(8): 721-736, 2017 08.
Article
en En
| MEDLINE
| ID: mdl-28694140
ABSTRACT
B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that microRNAs (miRNAs) - a class of non-coding RNAs that control gene expression - are involved in the regulation of B cell development and function. We provide here an overview of the current knowledge on the role of miRNAs and their relevant targets in B cell development, B cell activation, and B cell malignant transformation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ARN Neoplásico
/
Linfocitos B
/
Transformación Celular Neoplásica
/
Linfoma de Células B
/
MicroARNs
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos