Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.

Cook, Peter J; Thomas, Rozario; Kannan, Ram; de Leon, Esther Sanchez; Drilon, Alexander; Rosenblum, Marc K; Scaltriti, Maurizio; Benezra, Robert; Ventura, Andrea

Cook, Peter J; Thomas, Rozario; Kannan, Ram; de Leon, Esther Sanchez; Drilon, Alexander; Rosenblum, Marc K; Scaltriti, Maurizio; Benezra, Robert; Ventura, Andrea.

Afiliación

Cook PJ; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Thomas R; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Kannan R; Department of Molecular Biology, Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, New York 10065, USA.
de Leon ES; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Drilon A; Department of Molecular Biology, Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, New York 10065, USA.
Rosenblum MK; Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Scaltriti M; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Benezra R; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Ventura A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Nat Commun ; 8: 15987, 2017 07 11.

Article en En | MEDLINE | ID: mdl-28695888

Asunto(s)

Benzamidas/uso terapéutico; Brevicano/genética; Glioma/genética; Indazoles/uso terapéutico; Fusión de Oncogenes; Receptor trkA/genética; Animales; Benzamidas/farmacología; Sistemas CRISPR-Cas; Ensayos de Selección de Medicamentos Antitumorales; Estudios de Factibilidad; Femenino; Edición Génica; Glioma/tratamiento farmacológico; Humanos; Indazoles/farmacología; Ratones Endogámicos C57BL; Ratones Desnudos; Neoplasias Experimentales; Cultivo Primario de Células; Receptor trkA/antagonistas & inhibidores

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzamidas / Receptor trkA / Fusión de Oncogenes / Brevicano / Glioma / Indazoles Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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