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Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Guillard, Sandrine; Kolasinska-Zwierz, Paulina; Debreczeni, Judit; Breed, Jason; Zhang, Jing; Bery, Nicolas; Marwood, Rose; Tart, Jon; Overman, Ross; Stocki, Pawel; Mistry, Bina; Phillips, Christopher; Rabbitts, Terence; Jackson, Ronald; Minter, Ralph.
Afiliación
  • Guillard S; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK.
  • Kolasinska-Zwierz P; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK.
  • Debreczeni J; Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.
  • Breed J; Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.
  • Zhang J; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.
  • Bery N; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.
  • Marwood R; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK.
  • Tart J; Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.
  • Overman R; Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.
  • Stocki P; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK.
  • Mistry B; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK.
  • Phillips C; Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.
  • Rabbitts T; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.
  • Jackson R; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK.
  • Minter R; Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, UK.
Nat Commun ; 8: 16111, 2017 07 14.
Article en En | MEDLINE | ID: mdl-28706291
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas ras / Anticuerpos Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas ras / Anticuerpos Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido