Cerebrospinal Fluid Penetration Rate and Efficacy of Afatinib in Patients with EGFR Mutation-positive Non-small Cell Lung Cancer with Leptomeningeal Carcinomatosis: A Multicenter Prospective Study.

Tamiya, Akihiro; Tamiya, Motohiro; Nishihara, Takashi; Shiroyama, Takayuki; Nakao, Keiko; Tsuji, Taisuke; Takeuchi, Naoko; Isa, Shun-Ichi; Omachi, Naoki; Okamoto, Norio; Suzuki, Hidekazu; Okishio, Kyoichi; Iwazaki, Ayano; Imai, Kimie; Hirashima, Tomonori; Atagi, Shinji

Tamiya, Akihiro; Tamiya, Motohiro; Nishihara, Takashi; Shiroyama, Takayuki; Nakao, Keiko; Tsuji, Taisuke; Takeuchi, Naoko; Isa, Shun-Ichi; Omachi, Naoki; Okamoto, Norio; Suzuki, Hidekazu; Okishio, Kyoichi; Iwazaki, Ayano; Imai, Kimie; Hirashima, Tomonori; Atagi, Shinji.

Afiliación

Tamiya A; National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan atamiya@kch.hosp.go.jp.
Tamiya M; Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan.
Nishihara T; Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan.
Shiroyama T; Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan.
Nakao K; National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan.
Tsuji T; National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan.
Takeuchi N; National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan.
Isa SI; National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan.
Omachi N; National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan.
Okamoto N; Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan.
Suzuki H; Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan.
Okishio K; National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan.
Iwazaki A; Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Japan.
Imai K; Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Japan.
Hirashima T; Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan.
Atagi S; National Hospital Organization Kinki-chuo Chest Medical Center, Sakai, Japan.

Anticancer Res ; 37(8): 4177-4182, 2017 08.

Article en En | MEDLINE | ID: mdl-28739703

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Receptores ErbB/genética; Carcinomatosis Meníngea/tratamiento farmacológico; Quinazolinas/administración & dosificación; Afatinib; Anciano; Carcinoma de Pulmón de Células no Pequeñas/líquido cefalorraquídeo; Carcinoma de Pulmón de Células no Pequeñas/genética; Carcinoma de Pulmón de Células no Pequeñas/patología; Supervivencia sin Enfermedad; Exones/genética; Femenino; Humanos; Masculino; Carcinomatosis Meníngea/líquido cefalorraquídeo; Carcinomatosis Meníngea/genética; Carcinomatosis Meníngea/patología; Persona de Mediana Edad; Mutación; Inhibidores de Proteínas Quinasas/administración & dosificación

Palabras clave

Afatinib; cerebrospinal fluid penetration rate; epidermal growth factor receptor; leptomeningeal carcinomatosis

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinazolinas / Carcinoma de Pulmón de Células no Pequeñas / Carcinomatosis Meníngea / Receptores ErbB Tipo de estudio: Clinical_trials / Observational_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Año: 2017 Tipo del documento: Article País de afiliación: Japón

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