Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice.

Muthuramu, Ilayaraja; Amin, Ruhul; Postnov, Andrey; Mishra, Mudit; Aboumsallem, Joseph Pierre; Dresselaers, Tom; Himmelreich, Uwe; Van Veldhoven, Paul P; Gheysens, Olivier; Jacobs, Frank; De Geest, Bart

Muthuramu, Ilayaraja; Amin, Ruhul; Postnov, Andrey; Mishra, Mudit; Aboumsallem, Joseph Pierre; Dresselaers, Tom; Himmelreich, Uwe; Van Veldhoven, Paul P; Gheysens, Olivier; Jacobs, Frank; De Geest, Bart.

Afiliación

Muthuramu I; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium.
Amin R; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium.
Postnov A; Nuclear Medicine & Molecular Imaging, Department of Imaging & Pathology, Catholic University of Leuven, 3000 Leuven, Belgium.
Mishra M; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium.
Aboumsallem JP; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium.
Dresselaers T; Biomedical MRI, Department of Imaging & Pathology, Catholic University of Leuven, 3000 Leuven, Belgium; Department of Radiology, University Hospitals Leuven, 3000 Leuven, Belgium.
Himmelreich U; Biomedical MRI, Department of Imaging & Pathology, Catholic University of Leuven, 3000 Leuven, Belgium.
Van Veldhoven PP; Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine, Catholic University of Leuven, 3000 Leuven, Belgium.
Gheysens O; Nuclear Medicine & Molecular Imaging, Department of Imaging & Pathology, Catholic University of Leuven, 3000 Leuven, Belgium.
Jacobs F; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium.
De Geest B; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, Catholic University of Leuven, 3000 Leuven, Belgium. Electronic address: bart.degeest@kuleuven.be.

Mol Ther ; 25(11): 2513-2525, 2017 11 01.

Article en En | MEDLINE | ID: mdl-28822689

Asunto(s)

Cardiomegalia/terapia; Cardiomiopatías/terapia; Colesterol/metabolismo; Terapia Genética/métodos; Vectores Genéticos/metabolismo; Receptores de LDL/genética; Acetil-CoA C-Acetiltransferasa/genética; Acetil-CoA C-Acetiltransferasa/metabolismo; Animales; Aorta/cirugía; Biomarcadores/metabolismo; Cardiomegalia/etiología; Cardiomegalia/metabolismo; Cardiomegalia/mortalidad; Cardiomiopatías/etiología; Cardiomiopatías/metabolismo; Cardiomiopatías/mortalidad; Constricción Patológica/complicaciones; Constricción Patológica/metabolismo; Constricción Patológica/patología; Dependovirus/genética; Dependovirus/metabolismo; Femenino; Expresión Génica; Vectores Genéticos/administración & dosificación; Vectores Genéticos/química; Pruebas de Función Cardíaca; Hemodinámica; Ratones; Ratones Noqueados; Miocardio/metabolismo; Miocardio/patología; Receptores de LDL/deficiencia; Análisis de Supervivencia; Serina-Treonina Quinasas TOR/genética; Serina-Treonina Quinasas TOR/metabolismo

Palabras clave

adeno-associated viral vectors; cardiac hypertrophy; cholesterol-lowering therapy; gene therapy; gene transfer; heart failure; hypercholesterolemia; low-density lipoprotein receptor; metabolic remodeling; non-ischemic cardiomyopathy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores de LDL / Terapia Genética / Colesterol / Cardiomegalia / Vectores Genéticos / Cardiomiopatías Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica

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