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A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.
Khetarpal, Sumeet A; Zeng, Xuemei; Millar, John S; Vitali, Cecilia; Somasundara, Amritha Varshini Hanasoge; Zanoni, Paolo; Landro, James A; Barucci, Nicole; Zavadoski, William J; Sun, Zhiyuan; de Haard, Hans; Toth, Ildikó V; Peloso, Gina M; Natarajan, Pradeep; Cuchel, Marina; Lund-Katz, Sissel; Phillips, Michael C; Tall, Alan R; Kathiresan, Sekar; DaSilva-Jardine, Paul; Yates, Nathan A; Rader, Daniel J.
Afiliación
  • Khetarpal SA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Zeng X; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Millar JS; Biomedical Mass Spectrometry Center, Schools of the Health Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Vitali C; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Somasundara AVH; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Zanoni P; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Landro JA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Barucci N; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Zavadoski WJ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Sun Z; Staten Biotechnology BV, Nijmegen, the Netherlands.
  • de Haard H; Staten Biotechnology BV, Nijmegen, the Netherlands.
  • Toth IV; Staten Biotechnology BV, Nijmegen, the Netherlands.
  • Peloso GM; Biomedical Mass Spectrometry Center, Schools of the Health Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Natarajan P; argenx BVBA, Zwjnaarde, Belgium.
  • Cuchel M; FairJourney Biologics, Porto, Portugal.
  • Lund-Katz S; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
  • Phillips MC; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Tall AR; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Kathiresan S; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
  • DaSilva-Jardine P; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Yates NA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Rader DJ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nat Med ; 23(9): 1086-1094, 2017 Sep.
Article en En | MEDLINE | ID: mdl-28825717
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triglicéridos / Mutación Missense / Apolipoproteína C-III / Lipoproteínas Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Triglicéridos / Mutación Missense / Apolipoproteína C-III / Lipoproteínas Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos