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Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.
Noh, Hyun Ji; Tang, Ruqi; Flannick, Jason; O'Dushlaine, Colm; Swofford, Ross; Howrigan, Daniel; Genereux, Diane P; Johnson, Jeremy; van Grootheest, Gerard; Grünblatt, Edna; Andersson, Erik; Djurfeldt, Diana R; Patel, Paresh D; Koltookian, Michele; M Hultman, Christina; Pato, Michele T; Pato, Carlos N; Rasmussen, Steven A; Jenike, Michael A; Hanna, Gregory L; Stewart, S Evelyn; Knowles, James A; Ruhrmann, Stephan; Grabe, Hans-Jörgen; Wagner, Michael; Rück, Christian; Mathews, Carol A; Walitza, Susanne; Cath, Daniëlle C; Feng, Guoping; Karlsson, Elinor K; Lindblad-Toh, Kerstin.
Afiliación
  • Noh HJ; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA. noh@broadinstitute.org.
  • Tang R; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Flannick J; Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA, 02139, USA.
  • O'Dushlaine C; Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Shandong Middle Road, Huangpu Qu, Shanghai, 200001, China.
  • Swofford R; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Howrigan D; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Genereux DP; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Johnson J; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • van Grootheest G; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Grünblatt E; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Andersson E; GGZ inGeest and Department of Psychiatry, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
  • Djurfeldt DR; Department of Child & Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Neumünsterallee 9, Zurich, 8032, Switzerland.
  • Patel PD; Neuroscience Center Zurich, University of Zurich & ETH Zurich, Winterthurer Strasse 190, Zurich, 8057, Switzerland.
  • Koltookian M; Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurer Strasse 190, Zurich, 8057, Switzerland.
  • M Hultman C; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.
  • Pato MT; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.
  • Pato CN; Stockholm Health Care Services, Stockholm County Council, Stockholm, 14186, Sweden.
  • Rasmussen SA; Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA.
  • Jenike MA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA.
  • Hanna GL; Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
  • Stewart SE; Department of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA.
  • Knowles JA; Department of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA.
  • Ruhrmann S; Department of Psychiatry & Human Behavior, Brown Medical School, 345 Blackstone Boulevard, Box G-BH, Providence, RI, 02906, USA.
  • Grabe HJ; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA, 02215, USA.
  • Wagner M; Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA.
  • Rück C; BC Mental Health & Addictions Research Institute, UBC, 2255 Wesbrook Mall, Vancouver, BC, Canada, V6T 2A1.
  • Mathews CA; Department of Psychiatry & Behavioral Sciences, USC, 2250 Alcazar Street, Los Angeles, CA, 90033, USA.
  • Walitza S; Department of Psychiatry & Psychotherapy, University of Cologne, Kerpener Street 62, Cologne, 50937, Germany.
  • Cath DC; Department of Psychiatry & Psychotherapy, University of Medicine Greifswald, Fleischmannstrasse 8, Greifswald, 17475, Germany.
  • Feng G; Department of Psychiatry & Psychotherapy, University of Bonn, Regina-Pacis-Weg 3, Bonn, 53113, Germany.
  • Karlsson EK; German Center for Neurodegenerative Diseases, Sigmund-Freud-Strasse 27, Bonn, 53127, Germany.
  • Lindblad-Toh K; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Tomtebodavägen 18A, Stockholm, 17177, Sweden.
Nat Commun ; 8(1): 774, 2017 10 17.
Article en En | MEDLINE | ID: mdl-29042551
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Trastorno Obsesivo Compulsivo Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Trastorno Obsesivo Compulsivo Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos