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Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
Bernstock, Joshua D; Ye, Daniel; Smith, Jayden A; Lee, Yang-Ja; Gessler, Florian A; Yasgar, Adam; Kouznetsova, Jennifer; Jadhav, Ajit; Wang, Zhuoran; Pluchino, Stefano; Zheng, Wei; Simeonov, Anton; Hallenbeck, John M; Yang, Wei.
Afiliación
  • Bernstock JD; Stroke Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, Maryland, USA.
  • Ye D; Division of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute and National Institute of Health Research Biomedical Research Centre, University of Cambridge, United Kingdom.
  • Smith JA; UAB School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Lee YJ; Stroke Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, Maryland, USA.
  • Gessler FA; Division of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute and National Institute of Health Research Biomedical Research Centre, University of Cambridge, United Kingdom.
  • Yasgar A; Stroke Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, Maryland, USA.
  • Kouznetsova J; Division of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute and National Institute of Health Research Biomedical Research Centre, University of Cambridge, United Kingdom.
  • Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA; and.
  • Wang Z; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA; and.
  • Pluchino S; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA; and.
  • Zheng W; Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
  • Simeonov A; Division of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute and National Institute of Health Research Biomedical Research Centre, University of Cambridge, United Kingdom.
  • Hallenbeck JM; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA; and.
  • Yang W; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA; and.
FASEB J ; 32(3): 1677-1691, 2018 03.
Article en En | MEDLINE | ID: mdl-29146736
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Cisteína Endopeptidasas / Proteína SUMO-1 / Proteínas Adaptadoras Transductoras de Señales / Sumoilación Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Cisteína Endopeptidasas / Proteína SUMO-1 / Proteínas Adaptadoras Transductoras de Señales / Sumoilación Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos