miR-128 Regulates Genes Associated with Inflammation and Fibrosis of Rat Kidney Cells In Vitro.
Anat Rec (Hoboken)
; 301(5): 913-921, 2018 05.
Article
en En
| MEDLINE
| ID: mdl-29278451
ABSTRACT
microRNAs (miRNAs) regulate diverse cellular functions and signaling pathways via inhibiting the expression of their target genes. Given that miR-128 mediates mitogen-activated protein kinase signaling and production of reactive oxygen species and pro-inflammatory chemokines in various types of cells and tissues, and that miR-128 is differentially expressed in aged and diseased kidneys, we hypothesized that miR-128 may play key roles in kidney inflammation. Hence, in this study, we evaluated the biological effects of miR-128 in normal rat kidney (NRK) cells in vitro. Our results revealed that overexpression of miR-128 enhanced expression of genes associated with inflammation, pro-inflammatory cytokines and fibrosis in NRK cells. The recent reports showing that expression of miR-128 is increased in liver and lung fibrosis, together with the findings in this study, suggest that miR-128 may be a pro-fibrotic miRNA that regulates fibrosis in various tissues. Anat Rec, 301913-921, 2018. © 2017 Wiley Periodicals, Inc.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fibrosis
/
Regulación de la Expresión Génica
/
MicroARNs
/
Inflamación
/
Riñón
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Anat Rec (Hoboken)
Asunto de la revista:
ANATOMIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Singapur